Tendon and ligament injuries heal very slowly, and the prognosis is often uncertain. Main reason is the scar tissue formation in the in injury area during natural healing process. As the scar tissue does not tolerate stress in the manner of healthy tissue., the risk of re-injury is high.
TendoStem® is a treatment based on stem cell technology fro equine tendon and suspensory ligament injuries. Stem cells capable of differentiation are grown from the horse's own fat tissue and then injected to the injury area. This results in cell regeneration into normal tissue where creation of scar tissue is minimized. The result of the treatment is a durable and flexible structure.
Good results with stem cell treatment
Stem cells are cells that are still undifferentiated and can renew themselves. Adult stem cells are multipotent: for example, cells isolated from fat can differentiate for example into tendon and cartilage cells.
In the TendoStem® treatment, stem cells are taken from the horse's own fat tissue. The fat tissue is rich in stem cells – approximately 500 times the amount in the bone marrow. Fat sampling is a fast, safe and simple procedure. Additionally stem cells can be cultured faster from fay samples than from bone marrow. When stem cells have been injected into the injured tendon, they start forming new tissue.
The prognosis with stem cell treatment is excellent..
The best end result is achieved if the stem cell treatment is given as soon as possible after the injury after the inflammation stage but before the forming of scar tissue.
Histola Research Ltd as the marketer for Finland
Inquiries and
orders for TendoStem® sampling packages:
Histola Research Ltd
Phone: +358 (0)400 690 649
Email: info@tendostem.com
www.histola.com
N-vet as the marketer for Sweden
N-vet Läkemedel
Uppsala Science Park 751 83 Uppsala
Phone: +46-(0)18 57 24 30 / 31
Email: info@n-vet.se
www.n-vet.se
Information concerning other countries:
Phone: + 358 - (0)40-504 4423
Email: info@tendostem.com
Publications:
Leppänen et al, 2009: Management
of equine tendon and ligament injuries with expanded autologous adipose-derived
mesenchymal stem cells – a clinical study. Regenerative Medicine, November 4(6), Suppl. 2 (2009), World Conference of Regenerative Medicine, Leipzig, Germany 28-30.10.2009, Proceedings S21
Leppänen et al, 2009: Follow-up
of recovery of equine tendon and ligament injuries 18-24 months after treatment
with enriched autologous adipose-derived mesenchymal stem cells – a clinical
study. Regenerative Medicine, November 4(6), Suppl. 2 (2009), World Conference of Regenerative Medicine, Leipzig, Germany 28-30.10.2009, Proceedings S21
Dahlgren LA 2009. “Management of Tendon Injuries,
Chapter 115 & Stem Cell Therapy”, Chapter 199. In: Current Therapy
in Equine Medicine, 6th edition, Saunders.
Fortier et al 2008.
Regenerative Medicine for Tendinous and Ligament Injuries of Sport
Horses. Vet Clin Equine 24:191–201.